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Public Facts. Redfin Estimate. Similar Homes. Local rules require you to be signed in to see all of the details. Street View. Not For Sale. Redfin last checked: over 7 days ago. Year Built Nearby Similar Homes. Property Details for 10 Jefferson St 2 We'll show details for this property as soon as we have them. Learn more.

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Property History for 10 Jefferson St 2. Schools This home is within the Marblehead School District. GreatSchools Rating. Village School. L H Coffin. Marblehead Community Charter Public School.Many probes fall outside of coding regions and are not displayed on the Histogram.

The gene view histogram is a graphical view of mutations across SP7. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. Show more. This default peptide view shows a histogram of single base substitutions, colour coded by residue according to the colour scheme used in Ensembl.

Under this is shown the amino acid sequence and the Pfam protein structures, followed by complex mutations and insertions and deletions. The graphical view can be switched to cDNA coordinates by selecting from the "Coordinate system" options in the "Filters" panel on the left.

You can use the filters panel to select the types of data that are displayed. After adjusting a filter, press Apply filtersor press Reset filters to revert to the original, unfiltered display. You can see more information on the help pages. This section gives an overview of SP7, along with links to any related data and resources. This section shows the drugs associated with SP7 resistance mutations. In the tabs below you can see any other genes that have resistance mutations to the same drug sand the distribution of mutations that occur in those genes.

Histograms show the percentage of mutated samples for point mutations, CNV data and gene expression data. Moving your mouse over the histograms will show additional data. You can see additional information about the data presented here in the help pages. Note that you can also view the genome browser in a separate page. Note: in some web browsers the genome browser may display a blank content panel when switching between browser tabs or when returning to the page using the browser's Back button.

If this happens please click and drag the blank content panel to reload the genome browser. This section displays a series of charts that show the distribution of different types of mutations for SP7. The first chart in this section shows a summary of the types of mutation that have been observed in samples for this gene. The table shows the number of samples recorded as having a particular type of mutation, with the number in brackets giving the percentage of samples with that type of mutation.

Note that a sample may have more than one type of mutation, so the total number of samples determined by simply summing the values in the table may not match the total number of unique samples given under the table. You can see additional information about this data in the help pages. This tab displays a table of mutations for the selected gene. You can see more information in our help pages.

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This tab displays a table of fusions for the selected gene. The table currently shows only high value numeric copy number data. Copy number segments are excluded if the total copy number and minor allele values are unknown. Click here to include all copy number data. Normal; Z-Score within the range For some TCGA samples where minor allele information is not available the average ploidy value could not be calculated.

For CGP samples, Picnic algorithm is used to calculate the average ploidy. This page contains the complete Methylation data for the gene and filter selection s.This sunny first floor corner unit features updated eat-in kitchen with tiled floor and newer Samsung appliances. Move in ready condition. Spacious master bedroom and larger second bedroom with plenty of bight natural light.

Lots of closet space as well a extra designated storage. Condo Fee includes Heat and Hot Water. Plenty of guest parking. Close to downtown Danvers and Major highways and walking, bike trail. Coin operated Laundry in building. This One won't last! Redfin Estimate based on recent home sales. United States. California DRE If you are using a screen reader, or having trouble reading this website, please call Redfin Customer Support for help at Redfin Estimate.

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Estimated sale price.The perfect addition to any synthetic chemistry laboratory, the XtaLAB mini II single crystal X-ray diffractometer will enhance research productivity by offering affordable structure analysis capability without the necessity of relying on a departmental facility.

Instead your research group can rapidly analyze new compounds as they are synthesized in the lab without having to queue up in the departmental core facility. In many universities, the departmental single crystal X-ray diffractometer is considered off limits to students because of fear the instrument might be damaged by inexperienced users.

The XtaLAB mini II benchtop diffractometer provides the opportunity for students to learn single crystal X-ray analysis by actually using a fully functional diffractometer. This is not a black box instrument. No data quality compromises.

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Results delivered are unambiguous. X-ray source tube lifetime is extended by running a standard off-the-shelf X-ray tube at W.

To compensate for running at a lower power, a SHINE optic special curved monochromator is utilized to produce usable X-ray flux comparable to a standard X-ray diffractometer.

In addition, the XtaLAB mini II is equipped with a state-of-the-art two-dimensional semiconductor detector that is characterized by extremely low background noise and high sensitivity. The chief design requirement when creating the XtaLAB mini II single crystal X-ray diffractometer was that the structures produced would be publishable in the most demanding scientific journals.

The software provides all the tools you need to generate publication quality data that can be used to determine 3D structures from a variety of structure analysis packages. Designed around an easy-to-use graphical user interface, CrysAlis Pro can be operated under fully automatic, semi-automatic or manual control. CrysAlis Pro combines automated crystal screening, the fastest and most accurate strategy software available, concurrent data reduction and automatic small molecule structure solution.

Visual feedback is provided for each step with clear, color-coded guidance so that both novices and experts can collect high-quality data in the shortest time possible.

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AutoChem is an optional software package for the XtaLAB mini II and is the ultimate productivity tool for chemical crystallographers, offering fast, fully automatic X-ray structure solution and refinement during data collection. It is an alternative pre-experiment option, which is used to plan your full data collections. The Series Cryostream is the most robust, efficient and user-friendly liquid nitrogen based low temperature system available today.

Specific features include a superior laminar flow system, meaning virtually zero risk of icing, extremely quiet running and a fast-start system resulting in a cool-down time to K of just 20 minutes.

Benchtop Single Crystal X-ray Diffractometer.Author contributions: D. Reviewers: D. The essence of the adaptive immune response depends on the specificity of antigen receptors. We identified multiple TCR pairs shared between tumors, but not control samples.

Although recent reports have concluded that anticancer T-cell responses depend on patient-specific mutation-associated neoantigens, this study provides evidence that T cells also recognize shared antigens. Infiltration of T cells in breast tumors correlates with improved survival of patients with breast cancer, despite relatively few mutations in these tumors.

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To determine if T-cell specificity can be harnessed to augment immunotherapies of breast cancer, we sought to identify the alpha—beta paired T-cell receptors TCRs of tumor-infiltrating lymphocytes shared between multiple patients. Analysis of TCR sequences from primary tumors showed about fourfold more overlap in tumor-involved relative to tumor-free sentinel lymph nodes.

Harnessing these T cells may provide practical strategies to improve the shared antigen-specific response to breast cancer. Targeted immune-based therapies hold great promise toward improving breast cancer treatments 67. Studies have examined the immune phenotype of breast cancer tumor-infiltrating lymphocytes TILssuggesting that activated nonsuppressive T cells are of most benefit 8.

Further assessment of the TIL repertoire has broad implications for breast cancer therapies in antigen discovery, cancer vaccines, and adoptive cell therapies 7. Unique genetic recombination events are required to produce the T-cell receptor TCR reviewed in 9. The alpha- and beta-chains of the TCR undergo V D J recombination and heterodimerize in the thymus, resulting in a diverse T-cell repertoire that specifically recognizes peptide—MHC complexes.

Pairs are readily identified after expansion of T-cell clones, although culture of T cells can lead to substantial skewing of the repertoire 14which may select for T cells of varied affinity or avidity Single-cell sequencing identifies alpha—beta pairs, but is often laborious and has relatively low throughput. Tumor-reactive TCR pairs can be generated from activated T cells after culture with an autologous tumor using gene capture followed by frequency-based matching Recently, a high-throughput statistical method to determine the matched alpha—beta pairs was published, demonstrating high-fidelity pairing by this combinatorial analysis We sought to develop a method that was well-suited for limiting numbers of T cells ex vivo.

In addition, we reasoned that identified TCRs shared between patients would target shared antigens due to the low incidence of common mutations in breast cancer as well as the low mutational burden Redfin Estimate based on recent home sales. View estimate history. Track this home's value and get nearby sales activity Claim This Home. United States.

sp7 ma 2016 ln a2

California DRE If you are using a screen reader, or having trouble reading this website, please call Redfin Customer Support for help at Redfin Estimate:. Property Details. Property History. Tour Insights. Public Facts.

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sp7 ma 2016 ln a2

Street View. Not For Sale. Redfin last checked: over 7 days ago. Year Built Nearby Similar Homes. Property Details for 10 Jefferson St 2 We'll show details for this property as soon as we have them. Learn more. Property History for 10 Jefferson St 2. Schools This home is within the Marblehead School District.

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GreatSchools Rating. L H Coffin. Village School. Marblehead Veterans Middle School. Marblehead Community Charter Public School. Marblehead High School. School data provided by GreatSchools. School service boundaries are intended to be used as reference only. To verify enrollment eligibility for a property, contact the school directly.

Activity for 10 Jefferson St 2. Home Facts. Beds 3. Finished Sq. Unfinished Sq. Home facts updated by county records on Jul 17,


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